Lecture 19 11-11-10

Lecture 19 11-11-10 - Lecture 19 Lecture 19 Movement and...

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Unformatted text preview: Lecture 19 Lecture 19 Movement and Muscle Movement and Muscle 11 November 2010 11 November 2010 Skeletal Muscle Skeletal Muscle T-tubules (transverse tubules) propagate the action potential into the interior of the muscle fiber. SR (sarcoplasmic reticulum is the intracellular Ca ++ reservoir. Upon activation, it releases Ca ++ into the sarcoplasm (cytoplasm of muscle fiber). Sarcomere Sarcomere is often is often described as the described as the functional unit functional unit of of skeletal muscle. skeletal muscle. Skeletal Muscle Ca ++ binds to troponin and causes tropomyosin to move away from the myosin binding site of actin. Skeletal Muscle Sliding Filament Mechanism Contraction: thick & thin filaments slide over each other. I bands shorten; H zones shorten; A bands do not change in length. Result: sarcomeres shorten. Skeletal Muscle Cross-bridge cycle illustrates the molecular basis of the sliding filament mechanism: Skeletal Muscle Cross-bridge Cycle Functioning of cross-bridge cycle requires high cytosolic Ca ++ Excitation-Contraction Coupling...
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Lecture 19 11-11-10 - Lecture 19 Lecture 19 Movement and...

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