Lecture 19 11-11-10

Lecture 19 11-11-10 - Lecture 19 Lecture Movement and...

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Lecture 19 Lecture 19 Movement and Muscle Movement and Muscle 11 November 2010 11 November 2010
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Skeletal Muscle
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Skeletal Muscle T-tubules (transverse tubules) propagate the action potential into the interior of the muscle fiber. SR (sarcoplasmic reticulum is the intracellular Ca ++ reservoir. Upon activation, it releases Ca ++ into the sarcoplasm (cytoplasm of muscle fiber). Sarcomere Sarcomere is often is often described as the described as the functional unit functional unit of of skeletal muscle. skeletal muscle.
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Skeletal Muscle Ca ++ binds to troponin and causes tropomyosin to move away from the myosin binding site of actin.
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Skeletal Muscle Sliding Filament Mechanism Contraction: thick & thin filaments slide over each other. I bands shorten; H zones shorten; A bands do not change in length. Result: sarcomeres shorten.
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Skeletal Muscle Cross-bridge cycle illustrates the molecular basis of the sliding filament mechanism:
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Skeletal Muscle – Cross-bridge Cycle Functioning of cross-bridge cycle requires high cytosolic Ca ++
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Excitation-Contraction Coupling
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Excitation-Contraction Coupling
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