lecture 12

lecture 12 - Our goal is to read an organisms genome, and...

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Our goal is to “read” an organism’s genome, and predict as much as possible about the organism
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Many genes are regulated in response to CRP-- the CRP regulon . Many genes are regulated in response to O2-- the FNR regulon.
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The “stringent response” is another global response; the effector is the small molecule guanosine tetraphosphate (ppGpp). It affects the stability of interactions between RNAP and many promoters.
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Alternative sigma factors are another way to coordinate regulons.
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It’s easy to focus on one operon; but a typical cell has thousands of operons, each of which is transcriptionally regulated by more than one system. Keep in mind that the regulatory proteins have their own genes, and they are regulated too!
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Self-splicing introns have been found in Bacteria and Archaea. However, they are not nearly as prevalent or functional as they are in Eukarya.
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There are some differences between the domains with regard to translation--not surprising, given that the domains are deFned by differences in translation apparatus!
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This note was uploaded on 04/05/2011 for the course MIC 102 taught by Professor Appleman during the Fall '08 term at UC Davis.

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lecture 12 - Our goal is to read an organisms genome, and...

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