APC100 Repro MaleMegan1

APC100 Repro MaleMegan1 - Male Reproductive System...

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1 Male Reproductive System (mammals) APC 100 Winter 2011 Megan Roberts Office: 2216 Haring Ph: 752-9938 Email: [email protected] “Boys have a penis, girls have a vagina!” - Joseph, Kindergarten Cop Adapted from figs. 16.1a & 16.4a
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2 Sexual Differentiation Classification of Sex Repro Tract; Penis/Scrotum or Vagina/Clitoris/Labia (hormones) Testes or Ovary (SRY present?) Is Y chromosome present? (yes = male) •AMH and T induce Wolffian duct and regression of Mullerian duct •T converted to DHT to promote differentiation of external genitalia •SRY gene codes for signaling molecule stimulating the indifferent gonads to differentiate into testes •XX/XY sex chromosomes (human) •XXY individuals (Klinefelter's syndrome) •XO individuals (Turner syndrome) Phenotypic (Genital) Gonadal Genetic *SRY= sex-determining region of Y *AMH= anti-mullerian hormone *T = testosterone *DHT= dihydrotestosterone Sexual Differentiation – prenatal development of male and female gonads and Internal and External Reproductive Structures.
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3 Sexual Differentiation- Genetic Variation XX/XY XX/XO ZW/ZZ Sexual Differentiation- Reproductive Tract In the female - the paramesonephric or Mullerian ducts are retained • develop into the uterine tubes, the uterus, anterior vagina, oviduct, and cervix • the mesonephric ducts disappear almost completely In the male - the mesonephric or Wolffian ducts are retained • differentiates into the epididymis and the vas deferens • under androgen influence • Loss of paramesonephric due to anti-mullerian hormone (AMH) Caudal end of the embryo mesonephric duct (yellow) paramesonephric ducts (light purple) http://www.bionalogy.com/reproductive_system.htm Urogenital ridge site
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Sexual Differentiation- Reproductive Tract Note: Mullerian duct = paramesonephric duct Wolffian duct = mesonephric duct Sexual Differentiation-overview Undif. Gonad XX XY Y chromosome: SRY gene Testes Ovary Testosterone Male External Genitalia Female Ext. Genitalia Fertilization Sertoli Cell AMH No Y chromosome (Granulosa Cell) (Theca Cell) No T No AMH Leydig Cell Wolffian duct differentiation Male Ducts Mullerian duct regression T →→→→→ regression NO Mullerian duct regression
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This note was uploaded on 04/05/2011 for the course APC 100 taught by Professor Kelliewhited during the Spring '07 term at UC Davis.

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APC100 Repro MaleMegan1 - Male Reproductive System...

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