Smooth Muscle Physiology

Smooth Muscle Physiology - Activate 4/5/11 Neural...

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Click to edit Master subtitle style 4/5/11 Smooth Muscle Physiology
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4/5/11 Smooth Muscle in the Body Smooth muscle is non-striated and involuntary It is found lining and hollow tubes of the body Blood vessels GI tract and Sphincters Bladder and Ureters The Uterus 2 types of smooth muscle
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4/5/11 Smooth Muscle Pacemaker The pacemaker cells in the GI tract are the Interstitial Cells of Cajal (ICCs) These cells generate the Basal Electrical Rhythm (BER) via calcium waves When these cells reach threshold, the signal is passed through the smooth muscle cells (SMC) via gap junctions
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4/5/11 Excitation Contraction SMC contain actin, myosin, tropomyosin, calmodulin, caldesmon, and calponin (no troponin) Actin is anchored to dense bodies Ca binds to calmodulin to form
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4/5/11 Local Modulation of SMC Phosphorylation of MLC by Ca-calmodulin is required for crossbridge formation Ca-calmodulin binding is reduced by cAMP, ADP, ATP, and Adenosine cAMP phosphorylates MLCK at a site that blocks Ca-calmodulin binding
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Unformatted text preview: Activate 4/5/11 Neural Modulation of SMC Activity: Sympathetic Activation (Epi) Stimulates beta adrenergic receptors Increases cAMP Phosphorylates MLCK to block Ca-calmodulin binding Decreases ability Parasympathetic Activation (Methacholine) Stimulates muscarinic receptors Decreases cAMP Phoshorylates MLCK to increase 4/5/11 Neural Modulation of SMC Activity: Enteric Nervous The enteric nervous system in is embedded in the GI system Can operate independently or with the autonomic nervous system The enteric nervous system makes use of approximately 30 neurotransmitters 4/5/11 Schedule for the end of the quarter: No office hour on Mon, 2/21 (Presidents Day) Last lab on Tues 2/22 and last discussion on Thurs 2/24 Lab 7 reports due in the lab room Tues 3/1 by 5:30pm Lab 8 reports due in the lab room Tues 3/8 by 5:30pm Practical Exam practice questions due to smartsite Sun 2/27...
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Smooth Muscle Physiology - Activate 4/5/11 Neural...

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