BIS104_F10_Lecture4

BIS104_F10_Lecture4 - Topic II: Membrane structure and...

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Topic II: Membrane structure and dynamics 1. Membranes as barriers 2. Membrane structure 3. Two-dimensional fluid of lipid bilayer 4. Membrane-associated proteins
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1. Membranes as barriers for cells to be separated from their environment, and for intracellular compartments to be separated from the cytosol.
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Being barriers for a cell, the plasma membrane functions in ¾ Signal transduction process ¾ Material exchange with its surrounding environment ¾ Remodeling for motility
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A typical view of a membrane
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2. Membrane structure a. Amphipathic phospholipids (16-20 Cs)
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*Four major types of phospholipids found in lipid bilayer *Plus Phosphatidylinositol (PI) as a minor phospholipid. Important for signal transduction . They are asymmetrically distributed on the two leaflets of the lipid bilayer. *
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Ghosts of the red blood cell have been instrumental in the studies of cell membranes
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The Gorter and Grendel experiment (1925) They purified lipids from red blood cell (RBC) membranes. Using this trough, they
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This note was uploaded on 04/05/2011 for the course BIS 104 taught by Professor Scholey during the Fall '08 term at UC Davis.

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BIS104_F10_Lecture4 - Topic II: Membrane structure and...

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