BIS104_F10_Lecture8m

BIS104_F10_Lecture8m - BIS 104(1) F10 Topic IV: Secretory...

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BIS 104(1) F10 Topic IV: Secretory pathway 1. Protein traffic 2. Overview of secretory pathway 3. ER: where secretory pathway starts 4. Golgi: sorting secretory vesicles 5. Vesicle coats and destinations Announcements: 1. Quiz on Wednesday, Scantron 2000 required 2. No office hour on Wednesday
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a. Each Golgi stack has two distinct faces: 1) Entry face: cis 2) Exit fact: trans Special compartments: cis Golgi network (CGN): forward or backward trans Golgi network (TGN): onward to destinations Each cisterna of Golgi contains different enzymes to catalyze modifications of oligosaccharide chains on proteins QuickTime™ and a TIFF (LZW) decompressor are needed to see this picture. Dr. Chris Hawes, Oxford Brookes Univ.
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Demonstrating of different cisternae contain different enzymes involved in glycosylation medial cisternae trans cisternae
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b. Vesicular transport compartments for: biosynthetic-secretory pathway endocytic pathway retrieval pathways
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Demonstration of Retrograde Transport - Brefeldin A + Brefeldin A
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c. Vesicular transports take place between different cisternae of Golgi (by J. Rothman).
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BIS104_F10_Lecture8m - BIS 104(1) F10 Topic IV: Secretory...

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