BIS104_F10_Lecture9

BIS104_F10_Lecture9 - BIS BIS 104(1) F10 Topic IV:...

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IS 104(1) F10 BIS 104(1) F10 Topic IV: Secretory pathway 1. Protein traffic 2. Overview of secretory pathway 3. ER: where secretory pathway starts 4. Golgi: sorting secretory vesicles . esicle coats and destinations 5. Vesicle coats and destinations
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Plant and fungal cells contain vacuoles instead of lysosomes for identical purposes
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*Acrosome in sperm is a specialized lysosome Acrosome
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4. Coated Vesicles Coats are made of protein complexes. Three well characterized coats: lathrin- oated vesicles Clathrin coated vesicles COPI-coated vesicles COPII-coated vesicles
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* Morphologies of three types of coated-vesicles Coats are assembled during budding (formation) of vesicles.
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a. Clathrin-coated vesicles i. Clathrin: 3 heavy chains and 3 light chains assembled into the triskelion
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ii. Adaptor proteins: adaptins which bind to cargo receptors
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iii. Clathrin-coated vesicles in endocytosis: originated at the plasma membrane, and delivered to endosomes 1 3 2 4 Figure 15-19, Essential Cell Biology, 3/e.
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BIS104_F10_Lecture9 - BIS BIS 104(1) F10 Topic IV:...

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