BIS104_F10_Lecture10m

BIS104_F10_Lecture10m - BIS 104 (1) F10 Topic IV:...

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BIS 104 (1) F10 Topic IV: Transports between the nucleus and the cytosol 1. Structure of the nuclear envelope 2. Nuclear localization signal and nuclear import receptor 3. The Ran GTPase 4. Nuclear import and export
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Spatial regulation of protein synthesis in eukaryotes • mRNA translation takes place in the cytosol. • The nuclear envelope keeps functional ribosomes out of the nucleus • Resulting in preventing RNA transcripts from being translated into protein until they have been processed (spliced) and transported out of the nucleus into the cytosol.
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1. Structure of the nuclear envelope
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a. Traffic between the nucleus and the cytosol is regulated by nuclear pore complexes (NPCs) Molecules < 5000 daltons freely permeable The larger, the slower diffusion Molecules > 60 kDa barely enter by passive diffusion 3
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Macromolecular transport into and out of the nucleus
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b. Nuclear pore complex (NPC) Resolving the structure of NPCs: a 50-year expedition led by Dr. Hans Ris
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A NPC has an estimated molecular mass of ~125 million daltons And consists of more than 100 proteins, collectively called nucleoporins
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Nuclear Pore Complex (D’Angelo and Hetzer, 2008)
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Nuclear Pore Complex (Michael Rout, Rockefeller Univ.)
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2. Nuclear localization signal (NLS) and nuclear import receptor
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This note was uploaded on 04/05/2011 for the course BIS 104 taught by Professor Scholey during the Fall '08 term at UC Davis.

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BIS104_F10_Lecture10m - BIS 104 (1) F10 Topic IV:...

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