BIS104_F10_Lecture12m

BIS104_F10_Lecture12m - Only Myosin VI is a minus...

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BIS 104(1) F10 Topic V: The Cytoskeleton 1. Introduction 2. Intermediate Filaments 3. Actin Filaments (Microfilaments) 4. Microtubules Announcement: 1. Midterm exam on Wednesday 2. Review session on Monday Time: 7:30 – 9:30 pm Place: 1022 LS
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b. Plus end vs. minus end _ +
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c. Treadmilling of actin filaments
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*Actin polymerization
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d. Actin filaments for cell morphology and motility
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*Microvilli of the epidermal cells of the human small intestine
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e. Actin-binding proteins (ABPs) govern/regulate the behavior of actin filaments
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* Example : Using the ARP2/3 complex to nucleate new actin filaments
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*Actin polymerization at lamellipodium
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*Actin polymerization-driven cell migration
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* Monomeric G proteins play critical roles in regulating actin filament organization
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e. Actin filament-based motor proteins: myosins
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i. Myosin II: makes the thick filaments
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ii. Myosins walk along actin filaments
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iii. Myosin II-based muscle contraction
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*Muscle contraction upon the arrival of an action potential
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iv. Myosins have many different types (most are plus end-directed)
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Unformatted text preview: Only Myosin VI is a minus end-directed myosin motor *Myosins and diseases Cardiac Myosin II: Familial hypertrophic cardiomyopathy (FHC) Myosin V: Griscelli disease, Dilute in mouse Myosin VI: Snells Waltzer Myosin VII: Deafness, Autosomal Dominant (DFNA11), Deafness, Neurosensory, Autosomal Recessive (DFNB2) Myosin XV: DFNB3 v. Myosins can transport cargoes along actin filaments f. Actin-specific drugs Phalloidin: from the death cap Amanita phalloides Binds and stabilizes the actin filament Cytochalasin: from the fungal Drechslera species Caps the plus end of actin filaments Swinholide: from the sponge Theonella swinhoei Severs actin filaments Latrunculin: from the sponge Latrunculia magnifica Binds to actin subunits and prevents their polymerization 4. Microtubules a. MTs are polymers of - and -tubulin heterodimers...
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This note was uploaded on 04/05/2011 for the course BIS 104 taught by Professor Scholey during the Fall '08 term at UC Davis.

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BIS104_F10_Lecture12m - Only Myosin VI is a minus...

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