BIS104_F10_Lecture13m

BIS104_F10_Lecture13m - BIS 104(1 F10 Topic V The...

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BIS 104(1) F10 Topic V: The Cytoskeleton 1. Introduction 2. Intermediate Filaments 3. Actin Filaments (Microfilaments) 4. Microtubules Announcement: 1. Sample questions uploaded 2. Midterm test on Wednesday 3. Review session on Monday When: 7:30 – 9:30 pm Where: 1022 LS
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4. Microtubules a. MTs are polymers of α - and β -tubulin heterodimers
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b. MTs are polar filaments, and have structurally distinct plus and minus ends
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c . α - and β -tubulins are GTPase, but only -tubulin-bound GTP is exchangeable
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NOTE: GTP hydrolysis controls the growth of microtubules
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d . Microtubule dynamics i. Treadmilling: a result of GTP hydrolysis
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ii . Dynamic instability: another result of GTP hydrolysis
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Note: growing and shrinking microtubule ends
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e. Microtubule-organizing center (MTOC): - Centrosome, spindle pole body, basal body, etc. -Containing proteins which nucleate microtubules
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* The centrosome
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* γ -Tubulin ring complex nucleates microtubules (Wiese & Zheng, 2006. J Cell Sci)
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including those so-called MAPs (microtubule-associated protein)
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BIS104_F10_Lecture13m - BIS 104(1 F10 Topic V The...

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