BIS104_F10_Lecture15m

BIS104_F10_Lecture15m - BIS104 (1), Fall 2010 Topic VII:...

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BIS104 (1), Fall 2010 Topic VII: Cell Division Cycle 1. Dissecting cell division cycle 2. Maturation promoting factor (MPF) and cyclin- dependent kinase 3. Cell cycle checkpoints 4. Cytoskeleton and cell division 5. Cytokinesis 1
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iii. Kinase regulates the activity of their substrates by phosphorylation ¾ Cdk: Ser/Thr kinase, phosphorylates Ser/Thr residues with particular ¾ Phosphorylation often regulates/controls a protein’s function, activating/inactivating or increasing/decreasing 2
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iv. Regulation of Cdk activity o Genetic studies in fungi revealed the regulators in addition to MPF components o Cyclin B: encoded by cdc13 in fission yeast, CLB in budding yeast, and nimE in Aspergillus o An activating phosphatase: encoded by Cdc25 in fission yeast, MIH1 in budding yeast, and nimT in Aspergillus o Inhibitory tyrosine kinase: encoded by wee1 in fission yeast cdc2 ts Wild type wee1 ts 3
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¾ Regulation of Cdk activity by phosphorylation: becoming an active M- Cdk Cdk/Cdc2 ¾ Cak: Cdk activating kinase ¾ Wee1: Cdk inhibitory kinase ¾ Cdc25: Cdk activating phosphatase 5
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¾ Regulation of Cdc25 phosphatase by a positive feedback loop 6
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BIS104_F10_Lecture15m - BIS104 (1), Fall 2010 Topic VII:...

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