BIS104_F10_Lecture16m

BIS104_F10_Lecture16m - BIS104 (1), Fall 2010 Topic VII:...

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BIS104 (1), Fall 2010 Topic VII: Cell Division Cycle 1. Dissecting cell division cycle 2. Maturation promoting factor (MPF) and cyclin- dependent kinase 3. Cell cycle checkpoints 4. Cytoskeleton and cell division 5. Cytokinesis 1
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± Multiple checkpoints are present in the cell division cycle 3
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¾ Checkpoint mechanisms require at least three components 1. A sensory component that detects chromosome abnormalities 2. A signaling component that transmits information of abnormality 3. An effector that is capable of inhibiting the cell cycle machinery so that it is halted 4
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¾ Focusing on DNA damage and spindle assembly checkpoints 5
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i. DNA damage checkpoint ¾ DNA damage induces the activation of the Chk1 protein kinase ¾ Chk1 phosphorylates Cdc25 to inhibit its function: a G2 arrest 6
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¾ Candidates: ATM (ataxia telangiectasia mutated) protein and ATR (ATM related) 9 Ataxia telangiectasia (A-T): a rare recessive genetic disorder • A-T is a primary immunodeficiency disease • First signs: delayed development of motor skills, poor balance, and
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BIS104_F10_Lecture16m - BIS104 (1), Fall 2010 Topic VII:...

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