BIS104_F10_Lecture17

BIS104_F10_Lecture17 - Topic VII: Cell Division Cycle 1....

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BIS104 (1), Fall 2010 Topic VII: Cell Division Cycle 1. Dissecting cell division cycle 2. Maturation promoting factor (MPF) and cyclin- dependent kinase 3. Cell cycle checkpoints 4. Cytoskeleton and cell division 5. Cytokinesis 1
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Metaphase spindle in sea urchin (From Nikon Small World, 2006. By John Henson) 2 Microtubules and DNA
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¾ Motor proteins for spindle assembly and function 3 9 Kinesin 5: encoded by bimC and homologous genes. Essential for maintaining the bipolarity of the mitotic spindle.
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¾ Microtubule depolymerization may pull the kinetochore to the spindle pole during anaphase 4 4
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When chromosome segregation went wrong: 5 Down Syndrome (Trisomy 21)
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¾ Two stages of chromosome segregation during anaphase 7 7
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Forces generated during anaphase 8 1. Anaphase A: kinesins act at microtubule plus and minus ends to promote depolymerization. 2. Anaphase B: a. Plus end directed kinesin motors act at interpolar microtubules to slide them apart; b. Minus end directed dynein motors walk along astral microtubules to further separate the spindle poles.
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BIS104 (1), Fall 2010
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Unformatted text preview: Topic VII: Cell Division Cycle 1. Dissecting cell division cycle 2. Maturation promoting factor (MPF) and cyclin-dependent kinase 3. Cell cycle checkpoints 4. Cytoskeleton and cell division 5. Cytokinesis 11 Telophase HeLa cells (From Nikon Small World, 2010. By Paul Andrews) 12 Aurora B EGFP (green), Microtubules (red), Chromosomes (white) Cleavage furrow (animals) and Phragmoplast (plants) 13 Actomyosin ring Aaron Straight, Stanford 15 Sounds familiar? 16 Where to divide? 17 How does an animal cell know where to cleave? 18 Plant cell division 19 Phragmoplast Kinesin-12 , Microtubules , DNA + _ _ Actions for duplicating a cell 1. Actions of the Cdk/cyclin complexes 2. Microtubule reorganization 3. Actin microfilament reorganization 4. Membrane trafficking 5. Cleavage furrow vs. phragmoplast 6. Cytokinesis after chromosome segregation 7. Entering G1 phase after cytokinesis 21 How does a mitogen tell a cell to progress through the cell cycle?...
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BIS104_F10_Lecture17 - Topic VII: Cell Division Cycle 1....

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