BIS104_F10_Lecture18_Cholera

BIS104_F10_Lecture18_Cholera - How does it happen? How to...

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Why is cholera so deadly? 2 A severe diarrheal disease 200,000 500,000 cases per year Mortality rates reaching as high as 20 50% Caused by the bacterium Vibrio cholerae Infection through contaminated water and food The bacterium secrets the cholera toxin The cholera toxin causes severe diarrhea (dehydration) 2 3 hours from the onset of symptoms to death
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Unformatted text preview: How does it happen? How to deal with it? From CT (cholera toxin) to Cl-secretion CT is an enzyme. CT targets at a G protein. The G protein activates adenylate cyclase. Continuously produces cAMP. Activates protein kinase A. PKA phosphorylates CFTR (cystic fibrosis transmembrane receptor)....
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This note was uploaded on 04/05/2011 for the course BIS 104 taught by Professor Scholey during the Fall '08 term at UC Davis.

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BIS104_F10_Lecture18_Cholera - How does it happen? How to...

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