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Unformatted text preview: • How does it happen? • How to deal with it? From CT (cholera toxin) to Cl-secretion • CT is an enzyme. • CT targets at a G ‐ protein. • The G ‐ protein activates adenylate cyclase. • Continuously produces cAMP. • Activates protein kinase A. • PKA phosphorylates CFTR (cystic fibrosis transmembrane receptor)....
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- Fall '08
- cholera toxin