BIS104_F10_Lecture18a

BIS104_F10_Lecture18a - viii Changes of cell behaviors are...

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IS104 (1), Fall 2010 opic VIII: Signal Transduction BIS104 (1), Fall 2010 Topic VIII: Signal Transduction 1. Introduction 2. G-proteins and receptor kinases 3. G-protein-coupled receptors (GPCRs) 4. Protein kinase (enzyme)-coupled receptors 1
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1. Introduction i. Signals are converted from one form to another during transduction.
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ii. Cells send and receive signals: cell-cell communications Signal: mating factors (pheromones), peptides Receptor: tranmembrane proteins p p Effector proteins: include G protein and kinase Response: changes in gene expression Consequence: cell cycle arrest and mating
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iii. Signals (ligands) appear in different forms Dissolved gases: NO, ethylene Proteins Peptides Amino acids Fatty acid derivatives Steroids iv. Specific receptors for specific signals (ligands)
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v. Cell-cell communication takes place in four general ways
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vi. The same signal molecule leads to different responses in different target cells
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vii. Extracellular signals alter activities/behaviors of multiple intracellular molecules
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Unformatted text preview: viii. Changes of cell behaviors are mediated by second messengers Small molecules like Ca 2+ , cAMP Rapidly move from one site to another in the cytosol Relay the signals to the interior of the cell Fertilization triggered a Ca 2+ wave e t at o t gge ed a Ca a e ix. External signals are typically amplified through signal transduction pathways x. Responses to signals can be fast or slow xi. Signal pathways are often integrated and/or can distribute to ultiple effectors multiple effectors A mitogen triggers the cell cycle by activating/inactivating signal ansduction pathways transduction pathways 2. G-proteins and receptor kinases i. G-proteins Heterotrimeric G-proteins Discovery of G- rotein: 1994 Nobel Prize sco e y o G p ote 99 obe e Small monomeric GTPases (G-proteins) Discovery of oncogenes: 1989 Nobel prize Regulation of a monomeric GTPase Conformation difference between Ras-GDP and Ras-GTP 22...
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This note was uploaded on 04/05/2011 for the course BIS 104 taught by Professor Scholey during the Fall '08 term at UC Davis.

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BIS104_F10_Lecture18a - viii Changes of cell behaviors are...

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