BIS104_F10_Lecture19m

BIS104_F10_Lecture19m - BIS104 (1), Fall 2010 Topic VIII:...

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Topic VIII: Signal Transduction 1. Introduction 2. G-proteins, receptor kinases 3. G-protein-coupled receptors (GPCRs) 4. Protein kinase (enzyme)-coupled receptors and MAP kinase cascade BIS104 (1), Fall 2010 1
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¾ Switching off G-protein α subunit 4
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¾ Regulation of ion channels by G-protein 5
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¾ Pertussis toxin and whooping cough 9 Cause by the infection of the bacterium Bordetella pertussis 9 In 2009, nearly 17,000 cases of pertussis 9 Worldwide, there are 30-50 million cases of pertussis and about 300,000 deaths per year 9 Coughing fits due to pertussis infection can last for up to 10 weeks or more; sometimes known as the “100 day cough.” 9 Pertussis can cause serious illness in infants, children and adults and can even be life- threatening, especially in infants 9 Pertussis toxin (PTX) targets at G-protein and modifies it 9 The targeted Gi α subunit remain in the GDP bound form 9 The inhibitory effect is turned off 9 Cough 6
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¾ Regulation of enzyme activities by G-protein 7
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BIS104_F10_Lecture19m - BIS104 (1), Fall 2010 Topic VIII:...

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