BIS104_F10_Lecture20

BIS104_F10_Lecture20 - BIS104 (1), Fall 2010 Topic VIII:...

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Topic VIII: Signal Transduction 1. Introduction 2. G-proteins 3. G-protein-coupled receptors (GPCRs) 4. Protein kinase (enzyme)-coupled receptors and MAP kinase cascade 5. Cross-talks among signaling pathways BIS104 (1), Fall 2010 1
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¾ Examples of GPCRs ¾ Rhodopsins in the retina ¾ Activated by light ¾ T1R receptors in the tongue ¾ Sensing sweet tastes ¾ Sensing “umami” ¾ T2R receptors in the tongue ¾ Sensing bitter tastes ¾ Olfactory receptors ¾ Recognizing odors ¾ Mating pheromone receptors in yeast ¾ Mating between yeast cells 2
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i. Rhodopsin and cGMP-gated channels ¾ Signal: photon (light) ¾ Chromophore: 11-cis retinol 9 Binds to opsin to form rhodopsin 9 Isomerizes instantly upon absorption of photon ¾ Isomerization leads to conformational change in rhodopsin ¾ Conformational change in the G protein transducin (Gi) ¾ The α subunit of Gi activates cGMP phosphodiesterase ¾ cGMP level drops ¾ cGMP-gated cation channels close ¾ Reduced neurotransmitter release ¾ Free the postsynaptic retinal neurons from inhibition ¾ = excite these neurons 3
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Where are the rod cells? 4
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This note was uploaded on 04/05/2011 for the course BIS 104 taught by Professor Scholey during the Fall '08 term at UC Davis.

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BIS104_F10_Lecture20 - BIS104 (1), Fall 2010 Topic VIII:...

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