BIS104_F10_Lecture21m

BIS104_F10_Lecture21m - BIS104 (1), Fall 2010 Topic VIII:...

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Topic VIII: Signal Transduction 1. Introduction 2. G-proteins 3. G-protein-coupled receptors (GPCRs) 4. From receptors (hormone signaling) to MAP kinase cascade 5. Cross-talks among signaling pathways BIS104 (1), Fall 2010 2
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iv. From hormone signaling to MAP kinase cascade 3 ¾ What happens after Ras is activated by GTP binding? ¾ What is this protein named Raf?
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¾ Raf is a kinase, a MAP kinase kinase kinase (MAPKKK) for sure! 9 Ras-GTP turns on MAPKKK 9 Subsequently, MAPKK and MAPK will be turned on
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5 ¾ Activated MAP kinase enters the nucleus ¾ Targets: transcription factors (become phosphorylated) ¾ Inducing gene expressing MAPK
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6 ¾ Mitogen induces expression of cyclin D RTK/Ras/MAPK 9 Mitogen signaling is required for animal cells to pass the “restriction point” ¾ Example: wound heal stimulated by PDGF
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7 ¾ MAP kinase cascades are common signaling modules in eukaryotic cells 9 Receptors other than RTKs can also activate the cascades!
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¾ One of the best known examples is the response to mating pheromone in budding yeast 8
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This note was uploaded on 04/05/2011 for the course BIS 104 taught by Professor Scholey during the Fall '08 term at UC Davis.

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BIS104_F10_Lecture21m - BIS104 (1), Fall 2010 Topic VIII:...

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