BIS104_F10_Lecture22m-1

BIS104_F10_Lecture22m-1 - BIS104 (1), Fall 2010 Topic IX:...

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Topic IX: Programmed Cell Death (Apoptosis) 1. Introduction 2. Caspases and destruction of cytosolic proteins 3. Regulation of apoptosis by Bcl2 and related proteins 4. Induction of apoptosis BIS104 (1), Fall 2010 5
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1. Introduction i. Programmed cell death is a common developmental phenomenon 7 Millions of cells die every hour in our bodies >50% of nerve cells die soon after they are born Cell death balances cell division Example: liver injury and recovery Survive when it is needed Divide when another cell is needed Tightly regulated and irreversible
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Matching nerve cells with their target cells 8
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ii. Programmed cell death is different from cell necrosis 9 Cellular contents are recycled. Apoptotic cells die neatly!
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iii. Major steps in apoptosis 10 1. Cytoplasm shrinks and chromosomes condense 2. Nuclear fragmentation and cleavage of DNA 3. Fragmented cytoplasm and bleb formation 4. Formation of apoptotic bodies 5. Engulfing of apoptotic bodies by macrophages
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Engulfing by macrophages 12
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2. Caspases and destruction of cytosolic proteins
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BIS104_F10_Lecture22m-1 - BIS104 (1), Fall 2010 Topic IX:...

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