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BIS104_F10_Lecture24m

BIS104_F10_Lecture24m - 14*channels of 20 ‐ 200 nm v...

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Topic X: Cell-Cell Interaction 1. Plant cell wall and animal extracellular matrix 2. Cell-cell junctions 3. Stem cells and cloning BIS104 (1), Fall 2010 1 Announcement Office hour on 11/24: 10:30-11:30 AM
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2. Cell-cell junctions ¾ Organ specific adhesion of dissociated cells 2
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¾ Cells are organized into tissues with the ECM 3 CELL
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¾ Animal cells are bound together in two ways 4
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¾ Polarized epithelial cells form specialized cell-cell junctions 5
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i. Typical examples of cell-cell junctions 6 * * * * Adhesive junctions: 20-35 nm Tight junction: ~0 Gap junction: 2-4 nm
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ii. Tight junction: sealing spaces between cells 7
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¾ What is the tight junction made of? 8
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¾ Tight junctions create permeability barrier 9
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iii. Gap junction: forming channels between cells 10 ¾ Six connexins make a connexon ¾ Two connexons in register create a hydrophilic channel ¾ ~1.5 nm in diameter ¾ ~2-4 nm gap
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¾ Gap junction can be large or small 11
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¾ Gap junction allow molecules <1,000 daltons to pass 12 Examples: ions, ATP, glucose, amino acids and second messengers
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¾ The permeability of gap junction is gated 13
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iv. Plasmodesmata: allowing cytoplasmic exchange between neighboring plant cells
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Unformatted text preview: 14 *channels of 20 ‐ 200 nm v. Adhesive junctions: linking cells together to form embryos and tissues 15 Depletion of cadherin mRNA ¾ Transmembrane proteins mediate adhesion 16 ¾ Cadherins as examples: containing cadherin domain motif ¾ Homophilic binding between cadherins 17 Many other cell-cell adhesion proteins bind heterophilically! ¾ Homophilic binding promoted by Ca 2+ 18 ¾ Cadherin-dependent cell sorting 19 ¾ Heterophilic binding between lectins and oligosaccharides 21 Ca 2+-dependent binding between lectins and oligosaccharides ¾ Cadherins are attached to the cytoskeleton via linkers 23 ¾ The importance of the cytoskeletal attachment ! 24 ¾ Three typical adhesive junctions 25 9 Connecting to actin filaments: Adherens junctions 26 9 Contraction of actin filaments and neural tube formation 27 9 Desmosomes connect intermediate filaments between cells 28 9 Hemidesmosomes attach epithelial cells to the basal lamina ¾ Maintenance of cellular organization within tissues 29 3. Stem cells and cloning 30...
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