BIS104_F10_Lecture26m

BIS104_F10_Lecture26m - BIS104(1 Fall 2010 Topic XI...

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Topic XI: Uncontrolled Cell Proliferation: Cancer 1. Overview 2. Carcinogens 3. Oncogenes and tumor suppressor genes 4. Genetic disorders in cancer and treatments BIS104 (1), Fall 2010 1
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¾ Ames test: identifying potential carcinogens 2
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3 Stronger mutagenic activities stronger carcinogens
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4 ¾ Common known carcinogens Aflatoxin liver cancer
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5 ¾ Environmental influences: cancer epidemiology
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6 ¾ Identified preventable causes
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3. Oncogenes and tumor suppressor genes 7 ¾ Cancer-critical genes can be classified into two categories based on whether the corresponding mutations are dominant or recessive
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i. Oncogenes 8 o R. Weinberg: tumor contains a biologically active “oncogene”
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9
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¾ Different groups of oncogenes’ protein products 10 • Growth factors like PDGF • Receptors like EGF receptors • Plasma membrane GTPases like Ras • Non-receptor kinases like Src • Transcription factors like Myc • Cell cycle and death regulators like Cyclin D and Bcl-2 ± In normal circumstances, their expression, repression
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BIS104_F10_Lecture26m - BIS104(1 Fall 2010 Topic XI...

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