BIS104_F10_Lecture26m

BIS104_F10_Lecture26m - BIS104 (1), Fall 2010 Topic XI:...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Topic XI: Uncontrolled Cell Proliferation: Cancer 1. Overview 2. Carcinogens 3. Oncogenes and tumor suppressor genes 4. Genetic disorders in cancer and treatments BIS104 (1), Fall 2010 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
¾ Ames test: identifying potential carcinogens 2
Background image of page 2
3 Stronger mutagenic activities stronger carcinogens
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 ¾ Common known carcinogens Aflatoxin liver cancer
Background image of page 4
5 ¾ Environmental influences: cancer epidemiology
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 ¾ Identified preventable causes
Background image of page 6
3. Oncogenes and tumor suppressor genes 7 ¾ Cancer-critical genes can be classified into two categories based on whether the corresponding mutations are dominant or recessive
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
i. Oncogenes 8 o R. Weinberg: tumor contains a biologically active “oncogene”
Background image of page 8
9
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
¾ Different groups of oncogenes’ protein products 10 • Growth factors like PDGF • Receptors like EGF receptors • Plasma membrane GTPases like Ras • Non-receptor kinases like Src • Transcription factors like Myc • Cell cycle and death regulators like Cyclin D and Bcl-2 ± In normal circumstances, their expression, repression
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 26

BIS104_F10_Lecture26m - BIS104 (1), Fall 2010 Topic XI:...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online