BIS104_F10_Lecture27m

BIS104_F10_Lecture27m - 7 Gleevec blocks the kinase...

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Topic XI: Uncontrolled Cell Proliferation: Cancer 1. Overview 2. Carcinogens 3. Oncogenes and tumor suppressor genes 4. Genetic disorders in cancer and treatments Somatic and germline mutations BIS104 (1), Fall 2010 2
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4. Genetic disorders in cancer and treatments 3 i. A point mutation in an oncogene to make its protein product active constitutively.
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ii. c-myc overexpression due to chromosome rearrangement in human Burkitt’s lymphoma (B lymphocytes) 4
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¾ Abnormal chromosomes in cancer cells 5
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¾ Chromosomal translocation-induced gene fusion in Chronic Myeloid Leukemia (CML) 6
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¾ Treat Chronic Myeloid Leukemia (CML) with Gleevec
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Unformatted text preview: 7 Gleevec blocks the kinase activity of the Bcr-Abl fusion protein! Activation of RTK constitutively: Tel-PDGF fusion protein in leukemia 8 Formation of constitutively dimerized receptors via gene fusions 9 iii. Gene amplification: HER2/erbB2/neu in breast cancer 10 Amplified HER2 genes (red fluorescence by in situ hybridization) HER2 (Human Epidermal growth factor Receptor 2) and Herceptin 11 iv. Virus-induced cancer Cervical Cancer caused by viral infection (discovered by Harald zur Hausen) 12 13 Anybody druggable?...
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BIS104_F10_Lecture27m - 7 Gleevec blocks the kinase...

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