BIS 104 PQ 13 ans Spring 2010

BIS 104 PQ 13 ans Spring 2010 - CONCLUSION: PSNs are...

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BIS 104 PQ 13 ans Spring 2010 13. Describe the EXPERIMENTS that Mukouyama did with these mice. EXPERIMENT: Limb skin samples from both normal and mutant E15.5 mice were immunostained with fluor. Antibodies against PECAM-1; ephrinB2; BFABP; 2H3; and CX40. The staining patterns from the two sample sources were compared by scanning confocal fluor. microscopy. What CONCLUSION did he arrive at based on the results of these experiments?
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Unformatted text preview: CONCLUSION: PSNs are required (necessary) for the differentiation of small arterial blood vessels in the mouse limb skin. What cell types are specifically identified by these two markers? BFABP is expressed only by Schwann cells. Alpha-SMA is expressed only by smooth muscle cells (seen only around developing arteries, not veins)....
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