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BIS 104 PQ 16 ans spr 2010

BIS 104 PQ 16 ans spr 2010 - is predicted by the model...

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BIS 104 PQ #16 ans 16. a) In 2 – 3 concise sentences, describe the basic concepts stated in the Fluid Mosaic Model that attempt to explain the basis for bio-membrane structure and function relationships. The bilayer of a fluid-mosaic membrane is present in a fluid state, and individual lipid and protein molecules can move laterally within the plane of the membrane. Therefore, factors that affect membrane fluidity, such as temperature, lipid composition, aggregates of lipids and proteins in the form of rafts, may modulate the rate of lateral mobility. b) Summarize the observational and experimental evidence that has been developed in support of the Fluid Mosaic Model of bio-membranes. Is there any evidence that does not support this model? Fusion heterokaryons showing temperature-dependent intermixing of membrane proteins
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Unformatted text preview: is predicted by the model. Fluorescence recovery after photobleaching demonstrates the potential for membrane embedded proteins and lipids to move laterally at various rates, depending on inherent membrane fluidity/viscosity. Single particle tracking experiments show that individual molecules in the membrane may have a wide range of laterally mobility characteristics. Some do not move at all, others move freaquently, raidly and randomly. Freeze-fracture analyzed by SEM confirms the predicted presence of proteins embedded in a “sea of lipids”, and under certain circumstances, these proteins can move laterally within the bilayer. It is generally conceded that the fluid mosaic model accurately explains most , if not all, experimental observations on the behavior of biomembranes....
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