BIS 104 PQ 17 ans spr 2010

BIS 104 PQ 17 ans spr 2010 - and ephrinB2, affected by the...

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BIS 104 PQ ans #17 17. a) What does the Semaphorin3A (Sema 3A) gene code for in normal (wild type) mice? The Sema3A gene codes for an axon guidance factor (the protein neuregulin). b) What do the PSNs in the limb skin of Sema3A mutant mice look like? That is, how are they different from PSNs in wild type mice? ` The pattern of PSN growth is disorganized. The nerves appear more fasciculated and less finely branched. c) How is the immunostaining pattern of arterial endothelial cell markers, such as CX40
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Unformatted text preview: and ephrinB2, affected by the Sema3A mutation? The arterial markers follow the pattern of the disorganized nerves in the mutant. That is, the arteries do differentitate and are still aligned with the mutant nerves. d) What may we conclude from the experimental results that compare the Sema3A mice with the wild type mice? PSNs are sufficient to direct the patterning of arterial differentiation and vascular remodeling in limb skin....
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This note was uploaded on 04/06/2011 for the course BIS 104 taught by Professor Scholey during the Spring '08 term at UC Davis.

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