BIS 104 PQ 24 ans Spr 2010

BIS 104 PQ 24 ans Spr 2010 - E.g., COP I, COP II, clathrin,...

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BIS 104 PQ 24 ans Spr 2010 24. Cargo vesicles have been observed to move along micotubules (MTs) toward the “plus’ end at a rate of approximately 3 micrometers per second. Each “step” by the motor protein responsible for this transport is 8 nanometers (approx the length of one tubulin dimer). a. Which motor protein is required for this process? Conventional kinesin b. What is meant by a “processive’ motor protein? One “foot” of the motor protein is always in direct contact with it’s track (MTs) and thus is capable of long distgance, continuous travel without falling off the MT. c. What other molecules would most likely be involved in the transport of a vesicle along a MT? ATP. Also, specific recognition molecules embedded in the cargo wrapper or organelle being transported allow attachment or motor proteins to their cargo.
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Unformatted text preview: E.g., COP I, COP II, clathrin, kinectin. d. How many steps can this motor protein make in one second? 375 steps per second; or 2250 steps per minute. e. A neuron has to tranport acetylcholine packaged in a vesicle from near the nucleus, down the axon, to the tip for release at a synapse. The length of the axon is 600 micrometers. Assuming the motor protein doesnt stumble and fall off the MT, how many minutes will it take to deliver the cargo vesicle? 3.3 minutes to travel 600 micrometers. f. What two cytoplasmic parameters might influence the rate of cargo movement? i) availablility of ATP ii) Frictional resistance to motion due to cytoplasmic viscosity (high protein concentrations, particularly cytosleletal proteins, in the cytoplasm)....
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This note was uploaded on 04/06/2011 for the course BIS 104 taught by Professor Scholey during the Spring '08 term at UC Davis.

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BIS 104 PQ 24 ans Spr 2010 - E.g., COP I, COP II, clathrin,...

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