Lecture 17 practice problems

Lecture 17 practice problems - MCB121 Ubiquitin/Proteasome...

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MCB121 Ubiquitin/Proteasome practice problems 1. Describe two steps in the process of ubiquitination and degradation of a targeted protein that require ATP hydrolysis. 2. Which of the following is not a location to which a ubiquitin protein can be linked through its C-terminal end. A cysteine residue in another protein. A lysine residue of another protein. The N-terminus of another ubiquitin protein. A lysine residue in another ubiquitin. A cysteine residue in another ubiquitin protein. 3. Two particular lysines (K21 and K22) in I κ B appear to be targets for ubiquitination in the process of NF κ B activation. If you were to mutate these two lisines to arginines, what effect would you expect this to have on the activation of NF κ B in cells containing the mutant proteins?
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Solutions 1. Describe two steps in the process of ubiquitination and degradation of a targeted protein that require ATP hydrolysis. The E1 ubiquitin activating proteins utilize ATP to adenylylate ubiquitin as a
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Lecture 17 practice problems - MCB121 Ubiquitin/Proteasome...

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