MCB121W11 Final KEY

MCB121W11 Final KEY - Name Key Last, First MCB121, Page 1...

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Name Key MCB121, Page 1 of 13 Last, First Gasser, Burgess MCB121 Final Exam, Mar. 18, 2011 Instructions: There are thirteen pages in this exam including the cover sheet, please count them before you start to make sure all are present. Write your name on each page of the exam. Write your answers in the space provided below each question. If you need more space use the back of the page and indicate clearly that you have continued your answer on the back. Do not use additional paper. Amino acid Abbreviations Amino acid Abbreviations Alanine Ala A Leucine Leu L Arginine Arg R Lysine Lys K Asparagine Asn N Methionine Met M Aspartic acid Asp D Phenylalanine Phe F Cysteine Cys C Proline Pro P Glutamine Gln Q Serine Ser S Glutamic Acid Glu E Threonine Thr T Glycine Gly G Tryptophan Trp W Histidine His H Tyrosine Tyr Y Isoleucine Ile I Valine Val V
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Name Key MCB121, Page 2 of 13 Last, First Gasser, Burgess Question Value Score 1 15 2 10 3 18 4 5 5 33 6 15 7 4 8 8 9 6 10 9 11 5 12 12 13 12 14 16 15 32 Total 200 1. (15) For each of the following, place an “X” in the blank next to the one correct answer for each question (5 points each). c) (5) It was shown that an enhancer sequence on one plasmid could activate transcription from a minimal promoter on another plasmid if the two were linked together (linked as for links of a chain). Which of the following models for enhancer action is consistent with this result? Enhancers induce an unusual structure in the DNA that allows the two strands to be separated more easily for initiation of transcription. Enhancers disrupt the ability of nucleosomes to bind proximal regions allowing formation of the preinitiation complex (PIC). Enhancers promote melting of proximal regions facilitating initiation of transcription. X Enhancers are binding sites for proteins that can help recruit histone acetyl transferases that alter the structure of nearby chromatin to promote transcription. Enhancers are sites for entry of Pol II onto the DNA that can then scan in both directions for a proximal promoter.
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Name Key MCB121, Page 3 of 13 Last, First Gasser, Burgess b) Regulation of gene expression (from gene to active protein) happens at a variety of levels. A number of types of regulation include markers attached to lysines in particular proteins. Which of the following is NOT known to be involved in a step of such regulation. Linkage of a lysine residue to a methyl group. As in histone methylation Linkage of a lysine residue to a protein of around 8 to 9 kilodaltons. In ubiquitylation. Linkage of a lysine residue to an acetyl group. Histone acetylation. Linkage of a lysine residue to a small chain of proteins. Ubiquitylation. X Linkage of a lysine residue to a cysteine through an N-S bond. c) Why do C2-H2 zinc finger transcription factors often have three or more zinc finger domains?
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This note was uploaded on 04/06/2011 for the course MCB 121 taught by Professor Gasser during the Winter '09 term at UC Davis.

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MCB121W11 Final KEY - Name Key Last, First MCB121, Page 1...

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