Transcription Reg IIIa

Transcription Reg IIIa - MCB121 Regulation of Transcription...

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MCB121 Regulation of Transcription III 2/21/2008 Reading: Watson MBOG p. 601-607 (not Box 17-2) 608-611, 619-620, 624 Fig. 17-25, 599 Fig. 17-11, 708-711, 778-780, 708-711 (not Box 20-1), 662 box 19-1. Problems: Problem, MBOC 7-64, 7-65, 7-66. I. Nuclear hormone receptors A. Glucocorticoid receptor (GR) 2 C2C2 Zn fingers for binding and homodimerization Dimerization and nuclear localization induced by hormone activates or represses depending on binding sequence B. Other nuclear hormone receptors [thyroid hormone receptor (TR), progesterone receptor (PR), estrogen receptor (ER), retinoid X receptor (RAR, RXR) etc.] C. Gene regulation by: Enhancers with target sequences in gene regulatory regions Presence/absence of receptor (regulation of receptor genes) Presence/absence of hormone D. Thyroid hormone receptor (TR) - retinoic acid receptor (RXR) dimer recruits histone deacetylases in absence of thyroid hormone, but recruits histone acetylases (and basal apparatus) in presence of thyroid hormone
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This note was uploaded on 04/06/2011 for the course MCB 121 taught by Professor Gasser during the Winter '09 term at UC Davis.

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Transcription Reg IIIa - MCB121 Regulation of Transcription...

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