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Unformatted text preview: Tolerance & Withdraw Results from 1) cannabinoid-induced down regulation and desensitization of cannabinoid receptors in brain, 2) rapid receptor internalization Abruptly quitting marijuana use will cause withdraw symptoms (usually last 2-10 days) 1. Craving 2. Irritability 3. Agitation 4. Anxiety 5. Depressed mood 6. Reduction in food intake 7. Sleep disturbances Therapeutic Uses Cannainiod antagonists (rimonabant) have important medical actions (obesity, enhancement of learning during early states of dementia. Help people quit smoking) Dronabinol (Matinol)=synthetic THC ( agonist ) is used as an appetite stimulant in patients with AIDs, as well as to treat nausea etc. in cancer patients undergoing chemo, and may be used to stop muscle spasms Scientists predict that THC may have a major role in internal pain management in the future, as a protective agent after serve trauma and migraine relief Cooper, pp. 173-174 Diagram of a postsynaptic molecular entities of acetylcholine...
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- Spring '11