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Unformatted text preview: Tolerance & Withdraw • Results from 1) cannabinoid-induced down regulation and desensitization of cannabinoid receptors in brain, 2) rapid receptor internalization • Abruptly quitting marijuana use will cause withdraw symptoms (usually last 2-10 days) 1. Craving 2. Irritability 3. Agitation 4. Anxiety 5. Depressed mood 6. Reduction in food intake 7. Sleep disturbances Therapeutic Uses • Cannainiod antagonists (rimonabant) have important medical actions (obesity, enhancement of learning during early states of dementia. Help people quit smoking) • Dronabinol (Matinol)=synthetic THC ( agonist ) is used as an appetite stimulant in patients with AIDs, as well as to treat nausea etc. in cancer patients undergoing chemo, and may be used to stop muscle spasms • Scientists predict that THC may have a major role in internal pain management in the future, as a protective agent after serve trauma and migraine relief Cooper, pp. 173-174 Diagram of a postsynaptic molecular entities of acetylcholine...
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- Spring '11
- Morphine, Recreational drug use, Psychoactive drug, illegal drugs