Receptors - Receptors Definitions: 1. Agonist- a drug which...

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Receptors Definitions: 1. Agonist - a drug which mimicks a biological response 2. Antagonist- a drug which prevents a biological response 3. Orphan Receptor- a nuclear receptor that hs been cloned because of its similarity to known receptors, but without ligands. 4. Receptor- the binding or recognition component 5. Effector- the element involved in the biological response 6. Cooperativity- ligand binding at one site influences (positively or negatively) the bindings of the ligand 7. Desensitization- the lack or decline or a response to a constant stimulus Facts About 1000 receptors All of the receptors for neurotransmitters & peptide hormones that have been studied are on the surface of the cells o The only intracellular receptors are for steroid and thyroid hormones Sometimes drugs don’t act on the receptor but instead bind to a site that is adjacent to it and thus influence activity of the receptor. Continued administration of agonists can cause many receptors to desensitize and
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Receptors - Receptors Definitions: 1. Agonist- a drug which...

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