Julien pp - Julien pp. 556-587: Tetrahydrocannabinol...

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Julien pp. 556-587: Tetrahydrocannabinol Introduction Names for cannabis include: marijuana, hashish, charas, bhang, ganja, and sinsemilla Delta-9-tetrahydrocannabinol (THC) comes from the hemp plant Cannabis Sativa (Marijuana) and is the major psychoactive ingredient THC has a mild-sedative-hypnotic effect It binds to the cannabinoid receptors in the brain and mimic the action of anandamide , a naturally forming endogenous cannabinoid History Cannabis was used as a mild intoxicant for religious and psychedelic purposes several thousands of years ago It was introduced to Western culture around 1850 In the 1920’s it was considered evil By the 30’s it was considered a “narcotic” In the 40’s its reputation go worst and it became know as a “killer drug” responsible for crimes, other addictions, and social menace Today, nine states permit the use of marijuana for medical purposes Mechanisms of Action The THC receptor is a specific G protein-coupled receptor that both inhibits
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Julien pp - Julien pp. 556-587: Tetrahydrocannabinol...

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