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Unformatted text preview: on the presynaptic nerve terminals of dopamine, acetylcholine, and glutamine-secreting neurons Activations facilitates the release of transmitters and increases their actions in the brain most importantly it leads to an increase in dopamine levels Increased dopamine is the desired effects and the cause of the rush Tolerance and Dependence Nicotine does not appear to induce biological tolerance It does induce physiological and psychological dependence Withdraw is usually not life threatening but can last for months Withdraw symptoms include 1. Craving 2. Irritability 3. Anxiety 4. Anger 5. Difficulty concentrating 6. Increased appetite Arguably the hardest drug to quit Toxicity Cardiovascular disease Pulmonary disease Cancer Therapy Counseling Sustained release bupropion Nicotine gum Nicotine inhaler Transdermal nicotine path...
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- Spring '11