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Unformatted text preview: on the presynaptic nerve terminals of dopamine, acetylcholine, and glutamine-secreting neurons • Activations facilitates the release of transmitters and increases their actions in the brain most importantly it leads to an increase in dopamine levels • Increased dopamine is the desired effects and the cause of the “rush” Tolerance and Dependence • Nicotine does not appear to induce biological tolerance • It does induce physiological and psychological dependence • Withdraw is usually not life threatening but can last for months • Withdraw symptoms include 1. Craving 2. Irritability 3. Anxiety 4. Anger 5. Difficulty concentrating 6. Increased appetite • Arguably the hardest drug to quit Toxicity • Cardiovascular disease • Pulmonary disease • Cancer Therapy • Counseling • Sustained release bupropion • Nicotine gum • Nicotine inhaler • Transdermal nicotine path...
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This document was uploaded on 04/06/2011.
- Spring '11