How does the body handle drugs

How does the body handle drugs - -How does the body handle...

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-How does the body handle drugs -Absorption – the drug’s entrance into the bloodstream -can be done orally, rectally, parenterally (liquid injection), inhaled, through skin, through mucous membranes -specific examples of drugs for each of these categories can be found in the book -Distribution – movement of the drug throughout the body -every minute that heart pumps an amount of blood equivalent to all that within the circulatory system -blood circulation handles drugs differently, depending on how they are absorbed they take different routes to the brain -membranes that affect drug distribution are the -cell membranes that permeate small lipid soluble molecules -walls of the capillary vessels that allow for exchange with body tissues -blood brain barrier that includes a protective layer of cells that the drug must traverse (drugs with high lipid solubility and low molecular mass) -placental barrier which separates fetal blood from maternal blood. Drugs that cross this barrier do so mainly by passive diffusion -Metabolism – detoxification/breakdown of the drug -the liver plays a major role in this process -cytochrome p450 enzyme family has a major role in this
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This document was uploaded on 04/06/2011.

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How does the body handle drugs - -How does the body handle...

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