Chapter 10 – Drugs Used to Treat Bipolar Disorder

Chapter 10 – Drugs Used to Treat Bipolar Disorder

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Chapter 10 – Drugs Used to Treat Bipolar Disorder (Mood Stabilizers) Bipolar Disorder Characterized by recurrent episodes of mania and depression, associated with cognitive deficits Occurs in up to 5 percent of population If episode of mania or hypomania required hospitalization bipolar I Less severe bipolar II Higher suicide rates in untreated bipolar individuals than normal population Higher death rates due to substance abuse Two episodes of mania is enough to require long-term mood-stabilization treatment Treatment Issues Ideal mood stabilizer: o Stabilizes acute mania, mixed, and depressive symptoms o Does not induce switch from mania to depression/depression to mania o Prevents relapse to symptoms Classic mood stabilizer: Lithium o Effective, but has bad side effects/high risk of toxicity Neuronal Injury and Mechanisms of Drug Action Bipolar disorder a neurochemical disorder Evidence that bipolar disorder is accompanied by regional differences in neuronal
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Chapter 10 – Drugs Used to Treat Bipolar Disorder

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