Endoplasmic_Reticulum - Endoplasmic Reticulum 1. ER...

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Endoplasmic Reticulum 1. ER structure A. Rough ER B. Smooth ER 1. ER function 2. Mechanisms of Protein Transport A.Signal Recognition B. The Sec61 Translocator C. Mechanisms of transport Soluble proteins Single pass transmembrane proteins Multi-pass transmembrane proteins
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ER Structure Extensive lipid membrane 1/2 total eukaryotic cell 10% total cell volume Divides cytosol from lumen Extent varies with cell type
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Two types of ER Rough ER studded with ribosomes Smooth ER site of enzymes involved in lipid biosynthesis involved in detoxification
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ER function Provides all membrane and protein components of Golgi, ER itself, lysosomes, secretory vesicles and plasma membrane Synthesis and modification of proteins occurs based upon signal sequence recognition
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Mechanism of protein transport Signal recognition Signal sequence 16-30 residue sequence on N-terminus of peptide one or more + charged a.a. followed by stretch of 6-12 hydrophobic residues Mediated by molecule called signal recognition particle (SRP)
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Endoplasmic_Reticulum - Endoplasmic Reticulum 1. ER...

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