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Unformatted text preview: Tyrosine Kinase: similar but does not use alpha, beta, gamma insulin comes into receptor dimerization ADP--> ATP (phosphorlyation) kinase is activated phosphorlation of signal molecules induces hormone/ growth factor effects: increase glucose G RECEPTOR: hormone binds to receptor GDP exchanged for GTP beta and gamma release G(s) + alpha bind to target protein target protein sends out messages to other molecules GTP exchanged for GDP beta and gamma reattach-cycle can start over Adenylate Cyclase (cAMP): Hormone binds to receptor on cell membrane Receptor is activated G protein (alpha S) exchanges GDP for GTP Alpha separates from beta gamma and travels to adenylate cylase Takes in ATP and turns it into cAMP (releases phosphate) cAMP activates protein kinase à phosphorilates other proteins which creates a signal Phospholipase-C-Ca : hormone binds to receptor GDP--> GTP activates G protein (alpha Q) G protein(alpha q) activates phospholipase C hydrolyzes the lipid PIP2 Phospholipase C splits a membrane phospholipid into second messengers IP3 and DAG IP3 diffuses through cytoplasm to ER...
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This note was uploaded on 04/07/2011 for the course PHYS 100 taught by Professor Balassare during the Fall '10 term at Saint Louis.
- Fall '10