Chpt 4. Protein Structure and Function

Chpt 4. Protein Structure and Function - PROTEIN STRUCTURE...

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PROTEIN STRUCTURE AND FUNCTION
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Protein Structure and Function Primary, secondary, tertiary, quarternary levels of protein structure Ligand Binding Enzyme Catalysis Conformational Changes: Molecular Switches and Motors
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Primary, secondary, tertiary, quarternary levels of protein structure Primary structure: What is a polypeptide? Folding of the polypeptide: secondary and tertiary structure Domains in proteins Subunits interactions: quarternary structure Additional functional groups Protein structural diversity Methods for analyzing protein structure
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4-2
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Primary structure = Linear sequence of aa Example: DDEMTSVEIHGWYQQCV 4-3
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Protein folding assisted by intermolecular noncovalent bonds 4-4
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In Aqueous Solutions, Water Drives the Folding of Protein into Thermodynamically Stable Conformation 4-5
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Secondary Structure: Alpha helix (Fig 4-10)
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Secondary Structure: Beta sheet 4-10
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Tertiary Structure: Domains 4-19
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Tertiary Structure: Examples of Domains in Protein Subunits NAD-binding domain Lactate dehydrogenase Cyt b 562 V L region of IgG 4-20
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Conserved Primary Structure Yields Conserved Secondary and Tertiary Structure (as well as Conserved Function): Example-two serine proteases 4-21
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Quarternary structure: association of more than one protein subunit Homodimer Homotetramer 4-22
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Additional Functional Groups in Proteins Retinal (Chromophore) Heme (Carrier) 4-36
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Chpt 4. Protein Structure and Function - PROTEIN STRUCTURE...

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