Chpt. 16 Cellular communication

Chpt. 16 Cellular communication - General Principles of...

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Cell Communication (Ch.16) General Principles of Cell Signaling G-Protein-Linked Receptors Enzyme-Linked Receptors
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General Principles of Cell Signaling Signals can act over long or short range Each cell responds to a limited set of signals RECEPTORS relay signals via intracellular pathways Membrane surface vs intracellular receptors/signals Signal cascades act as a series of molecular switches
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Signal Transduction: Converting information from one form to another (16-2)
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Forms of Cell Signaling (16-3) (Long vs short distance)
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Examples of Biochemical Signals (See table 16-1) Hormones: Insulin, glucagon, estradiol, testosterone, adrenaline Local Mediators: EGF, PDGF, Histamine, NO, ethylene Neurotransmitters: Acetylcholine, GABA Wide range of types!!! Lipid soluble, peptides and proteins, small organic mol, dissolved gases
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T 16-1
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**Same signal, different cell, different response. (16-5)
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Cells depend upon multiple inputs of signals….(16-6)
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Signal cascades (16-7, 16-13): 1) physically transfer signal 2) transform signal 3) amplify signal 4) are flexible: signals can diverge 5) can be modulated by other factors 6) Lead to short and long-term changes RECEPTORS relay signals via intracellular pathways:
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intracellular receptors (16-8)
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Chpt. 16 Cellular communication - General Principles of...

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