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RelativeResourceManager

RelativeResourceManager - Supplement to Lecture Notes...

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Supplement to Lecture Notes additional comments on peptide bond formation and hydrolysis ........................... pages 2-3 supplemental notes on analyzing the ionization of weak acids ................................ page 4 1
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Hydrolysis favored ( G is negative for hydrolysis) Peptide bond lifetime is ~ 1000 years the rate constant for hydrolysis (k h ) is very small k f k h Recall : Thermodynamics does not indicate the rate at which a process will occur Peptide bond formation and hydrolysis 2
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There are several points that should be emphasized regarding the formation and hydrolysis of the peptide bond. These points are of fundamental importance and include the thermodynamics and the reaction rates. 1. The hydrolysis of the peptide bond is a favorable reaction with a G value of about 10 kJ/mol (2.4 kcal/mol). Thus, peptide bond formation does not occur spontaneously and has a G value of +10 kJ/mol. This indicates that protein synthesis by the ribosome, a supramolecular complex of RNA and protein, only occurs under physiologic conditions if it is coupled to a thermodynamically favorable reaction.
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