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Lecture17 - Lecture 17 Chapter 8 ENZYMES BASIC CONCEPTS AND...

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Chapter 8 E NZYMES B ASIC C ONCEPTS AND K INETICS Chapter 7 -entire chapter will be included on Exam II Lecture 17 1 Monday, October 6, 2008
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See Exam I Grade Distribution on Blackboard website Exams Folder 2 Monday, October 6, 2008
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Allosteric proteins (hemoglobin) (greek: allo =other + stereos =shape) cooperativity K 1 K 2 K 2 >K 1 low affinity high affinity 3 Monday, October 6, 2008
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O 2 binding to Hb is homotropic allosterism 2,3-BPG binding to Hb is heterotropic allosterism (other than normal ligand or substrate) Requires a multimeric protein S S R Can occur with a multimeric or monomeric proteins K 1 K 2 K 2 >K 1 R is a positive regulator K 2 < K 1 R is a negative regulator 4 Monday, October 6, 2008
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Concerted Model / MWC L 5 Monday, October 6, 2008
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Sequential Model / Koshland Model 6 Monday, October 6, 2008
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Enzymes Introduction How do they work? 7 Monday, October 6, 2008
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Enzymes: 1. accelerate biochemical reactions tremendously 2. most are proteins (a few RNAs act catalytically) 3. function in aqueous solvents 4. operate at mild temperatures, pressures, and pH
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