Lecture_No_2-Electron_Transport_I

Lecture_No_2-Electro - 1 1 2 phosphorylation 2 -1,3-BPG is an energy rich molecule with a greater phosphoryl-

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1 Electron Transport System
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2 There are 2  Ways to Make ATP 1.  Substrate phosphorylation 2.  Electron transfer-dependent oxidative  phosphorylation
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3 2 Glycolytic Reactions Make ATP by Substrate- level Phosphorylation --1,3-BPG is an energy –rich molecule with a greater phosphoryl-transfer potential than that of ATP. Thus, it can be used to power the ATP synthesis from ADP. --This is called substrate-level phosphorylation because the phosphate donor is a Substrate with high phosphoryl-transfer potential.
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4 2 Glycolytic Reactions Make ATP by Substrate- level Phosphorylation PEP has high phosphoryl-transfer potential, pyruvate (ketone) is much more stable than enol form.
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5 There are 2  Ways to Make ATP 1.  Substrate phosphorylation 2.  Electron transfer-dependent oxidative  phosphorylation
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6 How do we obtain lots of ATP? Glucose Reduced coenzymes (NADH + H + , FADH 2 ) O 2 H 2 O Glycolysis TCA ETC ATP Food (carbohydrates) ATP Little   Lo ts (~4 ATP) (~28-30 ATP) After TCA cycle, energy is extracted In the form of reduced Coenzymes, FADH2 and NADH Electron transport and Oxidative phosphorylation: Involved many steps, Sequestered in special environment. Glycolysis
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7 Minimal TCA Cycle Glucose Glucose Pyruvate Pyruvate NADH + H NADH + H CO CO NADH + H NADH + H CO CO GDP GDP GTP GTP FADH FADH NADH + H NADH + H 6C 6C 4C 4C 4C 4C ( ( 2C 2C ) ) CoASH CoASH CH CH 3 C C -SCoA -SCoA O O 1 GTP 1 GTP 3 NADH 3 NADH +1 FADH +1 FADH 2 10 ATP/cycle 10 ATP/cycle And releases And releases two CO two CO 2 NOTE: 1 NADH NOTE: 1 NADH 2245 2.5 ATP; 1 FADH2 2.5 ATP; 1 FADH2 2245 1.5 ATP; 1 GTP 2245 1 ATP so get 1 + 7.5 + 1.5 = 10 ATP/cycle 1 ATP so get 1 + 7.5 + 1.5 = 10 ATP/cycle NADH + H NADH + H NADH + H NADH + H
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8 Where in the cell does electron transport and  oxidative phosphorylation occur?
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9
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10 Mitochondria Permeable Outer Mtch Membrane Intermembrane Space Inner Mtch Membrane Matrix TCA enzymes β -oxidation ATP synthase e - transport chain M DNA
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11 Mitochondria --A mitochondrion is bounded by a double membrane, with an intermembrane space. --Outer M: permeable to most ions and small molecules
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This note was uploaded on 04/11/2011 for the course BCHM 562 taught by Professor Staff during the Winter '08 term at Purdue University-West Lafayette.

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Lecture_No_2-Electro - 1 1 2 phosphorylation 2 -1,3-BPG is an energy rich molecule with a greater phosphoryl-

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