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Unformatted text preview: Lecture 39: DNA repair Lecture 39 (4/11/11) DNA repair Reading assignment: pp. 289 ­92, 993 ­8 Problems: N&C ch. 8, #6 ­7, ch. 25, #12 ­13 SG p. 318, #4, 6 Fig. 26 ­39 Nelson & Cox. Lehninger Principles of Biochemistry, 5th ed. Freeman Publishing Company. 1 Lecture 39: DNA repair Different types of spontaneous mutaVons generated by toxic chemicals in the environment Sites known to be modified by spontaneous oxidaVve damage ( ) Sites suscepVble to hydrolyVc damage ( ) Sites suscepVble to uncontrolled methylaVon ( ) Figure 5-44 Molecular Biology of the Cell (© Garland Science 2008) 2 Lecture 39: DNA repair 3 Lecture 39: DNA repair Common sources of spontaneous mutaVons DeaminaVon of C DepurinaVon Figure 5-47 Molecular Biology of the Cell (© Garland Science 2008) 4 Lecture 39: DNA repair uracil Figure 5-49 Molecular Biology of the Cell (© Garland Science 2008) 5 Lecture 39: DNA repair 6 ...
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