22_printouts - Announcements / review Lecture 22 Reading...

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Announcements / review Lecture 22 Reading for today: pages 615-623, 626-628, 630-638 Reading for tomorrow: pages 647-656 (Study for quiz, postpone the reading!) Assigned problems: Ch.16: #3, 4, 10a, 10b, 28, 30 SG: p.214: #15; p.216: #4a, 4c, 4d Yesterday : Fermentation, Gluconeogenesis Pyruvate dehydrogenase Today : Citric Acid Cycle
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Acetyl-CoA Acetyl- CoA is major player in metabolism ! Most nutrients that will be used for energy are converted into acetyl-CoA before entering the Citric Acid Cycle . (Don ʼ t memorize the structure of CoA!) Do remember this structure of Acetyl-CoA! Some+mes called “CoA‐SH”
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Oxidation of Pyruvate PYRUVATE + CoA + NAD + ACETYL‐CoA + CO 2 + NADH Pyruvate (from glycolysis, or from oxidation of lactate) is transported into the: ( just like at the beginning of ________________ ). Then, in mito: Involves 5 coenzymes: 2 that are modiFed in the process: and 3 that are not, but participate in catalysis: The three that participate in catalysis are _______________ to the complex. Pyruvate Dehydrogenase : converts pyruvate to Acetyl-CoA by: Yes, know this reac±on for midterm!
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4 0 ‐structure : Multiple (dozens) copies of each enzyme. Pyruvate Dehydrogenase is a huge protein complex!
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22_printouts - Announcements / review Lecture 22 Reading...

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