23_printout - Fatty acyl-CoA is then transported into...

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Lecture 23 Reading for today: pages 647-656 Reading for Monday: pages 707-732 Assigned problems: N&C: Ch. 17: #3, 10 CHRIS’ OFFICE HOURS TOMORROW ARE CANCELLED (email me if you would like to setup an appointment) Yesterday: PDH and the Citric Acid Cycle Today: Fat catabolism = Harvesting energy from fat! Announcements / review
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Absorption and transport of dietary fat
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Fat is transported through blood by lipoprotein particles Chylomicrons are a type of lipoprotein particle : Composed of : Other lipoprotein particles: VLDL LDL HDL (more on this in lecture 27)
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Adipocytes (fat cells) main function: Release and transport of fatty acids from adipocytes Signal that body needs more energy: Glucagon (opposite signal to insulin) glucagon A signaling cascade (more in lecture 28) Leads to activation of Lipase : hydrolyzes TAG into Fatty acids are transported in blood by binding to albumin (a protein) Glycerol is converted into:
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Fatty acids are activated by CoA in the cytoplasm
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Unformatted text preview: Fatty acyl-CoA is then transported into mitochondria Fatty acyl-CoA Fatty acyl-Carnitine Fatty acyl-Carnitine Fatty acyl-CoA This is the regulated step of fatty acid catabolism! The pool of fatty acyl-CoA in the cytoplasm is used to synthesize membrane lipids: Cells need to balance needs of: Also, this process keeps cyto and mito pools of CoA separated => additional level of control. -oxidation of fatty acids Repeat! One round of -oxidation: Yields: Need to know structures, types of reactions (hydration) Energy accounting for fatty acids Fat catabolism: 1 16-carbon fatty acid = 8 Acetyl-CoA + 28 e- 8 Acetyl-CoA = (8 CAC) = 64 e- + 8 GTP so 1 16-carbon fatty acid = 92 e-+ 8 GTP Each e-will yield about 1 ATP -ox: CAC: PALMITOYL-CoA + 7CoA + 7FAD + 7NAD + + 7H 2 O TAKING THE 16-C PALMITIC AS THE EXAMPLE: 8ACETYL-CoA + 7FADH 2 +7NADH + 7H +...
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This note was uploaded on 04/08/2011 for the course BIO BM 3350 taught by Professor Blakenship during the Spring '11 term at Cornell University (Engineering School).

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23_printout - Fatty acyl-CoA is then transported into...

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