28_printout - Announcements / review Lecture 28 Reading for...

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Lecture 28 Reading for today: pages 419-420, 422-433, 569-577 Reading for tomorrow: pages 540-541, and HANDOUT download from website: Course Documents > Reading assignments (“The Control of the Metabolic Switch in Cancers…”) Assigned problems: SG: p. 164: #2, 3; p. 166: #2e Thursday: Lipid biosynthesis Today: Global metabolic regulation mechanisms ( Signaling ) Announcements / review
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Local versus global signaling Local signaling: what is the state of the cell? Global signaling: what is the state of the tissue, organ, or organism? Signal transduction : biochemical information transfer. Usually
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Signaling affects enzyme regulation We ʼ ve seen before how enzymes can be regulated: [enzyme], covalent modifcation, allostery
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Adenylate Kinase : 2 ADP AMP + ATP Consuming ATP generates ADP, Remember, cells want to keep [ATP] nearly constant: why ? [AMP] is a sensitive measure of cellular energy needs: [AMP] is a nearly universal local signal AMPK regulates several metabolic pathways:
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This note was uploaded on 04/08/2011 for the course BIO BM 3350 taught by Professor Blakenship during the Spring '11 term at Cornell University (Engineering School).

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28_printout - Announcements / review Lecture 28 Reading for...

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