29_printout - Announcements / review Lecture 29 Reading for...

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Lecture 29 Reading for today: pages 540-541, and HANDOUT download from website: Course Documents > Reading assignments (“The Control of the Metabolic Switch in Cancers…”) Yesterday: Global metabolic regulation mechanisms ( Signaling ) Today: Metabolism and Disease Announcements / review
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In general : Either: or more frequently: Most prominent metabolic disease: Diabetes: Type 1 (“juvenile”): problems ___________ loss of the pancreatic β -cells that _________(usually autoimmune) Type 2 : (“late-onset”): problems ______________ (“insulin-resistance”) too much fat => Adipocytes too full, In both types: Cells: Excess glucose in blood and: Many diseases are caused by defects in metabolism
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Otto Warburg: Noticed many (but not all) tumors: Do not consume much oxygen or: Do consume A LOT of glucose and: Which metabolic pathway(s) are such cells doing?? Why not consume oxygen? Tumors are initially in an:
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This note was uploaded on 04/08/2011 for the course BIO BM 3350 taught by Professor Blakenship during the Spring '11 term at Cornell.

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29_printout - Announcements / review Lecture 29 Reading for...

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