35_printout - Lecture 35: Chroma0n Structure Lecture...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Lecture 35: Chroma0n Structure Lecture 35 (4/4/11) Chroma0n Structure Reading assignment: pp. 962 ­71. Problems: SG p. 306, #4 Note: Line and Sine elements are s0ll retrotransposing in modern day cells. It is es0mated by some that 1/ 600 muta0ons that cause significant gene0c disease are the result of retrotransposi0on. 1 Lecture 35: Chroma0n Structure DNA wrapped around a nucleosome core (histone octamer) 100 Å 2 Lecture 35: Chroma0n Structure A type I topoisomerase in animal cells introduces nega:ve supercoils in steps of 1 30 nm 3 Lecture 35: Chroma0n Structure A par:ally unraveled human chromosome, revealing numerous loops of DNA a?ached to a scaffold ­like structure. A model for the higher order structure of eukaryo:c chromosomes 10 nm Fiber 2 nm 4 Lecture 35: Chroma0n Structure Three models for DNA replica:on (a) Conserva:ve (b) Semiconserva:ve (c) Dispersive AJer one genera:on AJer two genera:on 5 Lecture 35: Chroma0n Structure 6 ...
View Full Document

This note was uploaded on 04/08/2011 for the course BIO BM 3350 taught by Professor Blakenship during the Spring '11 term at Cornell University (Engineering School).

Ask a homework question - tutors are online