HW 1 - kinetic efficiency is similar to AchE. Explain this...

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How do enzymes work? 1. What was the first enzyme to have its 3D structure determined by x-ray crystallography? How did this achievement support transition-state theory? 2. Acetylcholine esterase (AchE) catalyzes the following reaction through a covalent intermediate. Which of the following is the best inhibitor of AchE and why? 3. AchE binds its substrate much tighter than carbonic anhydrase (CA), yet CA’s overall
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Unformatted text preview: kinetic efficiency is similar to AchE. Explain this in terms of Michaelis-Menten variables. How do the Km of each enzyme relate to the physiological concentration s of their substrates? 4. What does it mean for an enzyme to be perfectly evolved? Explain....
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