DNARNA-Part2 - DNA-binding proteins can bend DNA in a...

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Interwinding of the two antiparallel strands produces a structure that has two distinct helical grooves between the sugar-phosphate backbones. One of the grooves is much wider ( major groove ) than the other ( minor groove ); this disparity arises from the geometry of the base pairs.
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Noncanonical DNA structures It is now recognized that DNA is not a straight, monotonous, and uniform structure. Instead, DNA forms unusual structures, such as - cruciforms - triple - and, possibly, quadruple-strand complexes - bends and also it interacts with miscellaneous DNA-binding proteins. Variations in specific DNA structure or conformation are favored by specific DNA sequence motifs.
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-DNA sequences with runs of four to six adenines phased by 10-bp spacers produce bent conformations -A number of
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Unformatted text preview: DNA-binding proteins can bend DNA in a protein-DNA complex-Inter- and intra-strand cross-linked DNA adducts can also bend DNA (cisplatin)-Inverted repeats are quite widespread within the human genome and often found near putative control regions or at origins of DNA replication-It has been speculated that inverted repeats may function as molecular switches for replication and transcription Work in the 50s and 60s showed that some combination of sequences formed triple-strand complexes. For example, a thymine can selectively form two Hoogsteen H bonds to the adenine of A-T pair. Likewise, a protonated cytosine can form two Hoogsteen H bonds with the guanine of a G-C pair, resulting in a base triplet isomorphous to the T-A-T...
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This note was uploaded on 04/09/2011 for the course CHEM 4461 taught by Professor Max during the Spring '08 term at Lamar University.

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DNARNA-Part2 - DNA-binding proteins can bend DNA in a...

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